The Duchossois Family Institute: Harnessing the Microbiome and Immunity for Human Health was established on May 24, 2017, with a $100 million gift from Janet and Craig Duchossois and The Duchossois Family Foundation.
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The Duchossois Family Institute (DFI) at the University of Chicago Medicine promotes wellness through groundbreaking science on the immune system, genetics, the microbiome, and their shared environments.

Introducing a new science of wellness, the DFI aims to maximize good health and the economic, social, and personal benefits it delivers.

The DFI comprises a multidisciplinary team of scientists, physicians, data analysts, and entrepreneurship specialists who work together to accelerate development of this innovative, paradigm-shifting approach to health.

Learn about new research and discoveries in the new science of wellness on our blog. Read WellNews

With a research, clinical, and entrepreneurial infrastructure, the Duchossois Family Institute aims to reduce the time it takes to bring scientific breakthroughs from concept to market.

Research and Discovery

Research breakthroughs by DFI scientists and University partners increase our understanding of immunology, genetics, and the microbiome.

Treatments and Interventions

Discoveries are translated into potential new treatment options, and scientists conduct clinical trials to test intervention safety and efficacy.

Business Development

Partnerships with industry and investors bring new interventions to market.

Shared Resources Drive Discovery

The DFI team concentrates its efforts on driving research and discovery and translating breakthroughs into interventions that improve health. Six centralized research and discovery platforms accelerate success and allow faculty, clinicians, trainees, and students to work together efficiently:

Clinical Biorepository and Translation

Microbial Cultivation and Analysis

Next-Generation Biomarkers and Metabolomics

Medicinal Chemistry

Microbial Sequencing and Analysis

Data Integration & Analytics: Microbiome Data Commons

Benefiting from the University of Chicago’s strengths in genomics, the immune system, the microbiome, data analytics, and entrepreneurship, the Duchossois Family Institute partners with organizations and multidisciplinary centers from across the University, including:

Argonne National Laboratory
Marine Biological Laboratory
Microbiome Center
Institute for Molecular Engineering
Polsky Center for Innovation and Entrepreneurship

Senior Operations Team

The Senior Operations Team oversees research at DFI and leads the translation of discoveries into clinical breakthroughs and treatments.

T. Conrad Gilliam

Eugene Chang

Yoav Gilad

Chuan He

Robert Grossman

Faculty Leadership Cabinet

The Faculty Leadership Cabinet works with the Senior Operations Team on new faculty recruitment, proposal evaluations, and the distribution of pilot awards and postdoctoral fellowships.

John Alverdy

Erika Claud

Sean Crosson

Bana Jabri

Samuel Volchenboum

A History of Giving

The Chicago-area Duchossois family has a deep commitment to supporting science and medicine. Family members spanning three generations lead The Duchossois Family Foundation, a nonprofit organization that helps fund innovative programs in wellness and education.

To date, the Duchossois family has donated $137 million to drive innovation and transformative care at UChicago Medicine. Over nearly four decades, their generosity has supported treatment and diagnostic centers, research institutes, endowed professorships, and several cancer research funds. Some of their most transformative gifts to the University:

Cancer research

Richard Duchossois establishes the Beverly E. Duchossois Cancer Fund in memory of his wife. It marks the beginning of the Duchossois family’s support of UChicago Medicine.

DCAM building

The Duchossois family donates $21 million to fund the Duchossois Center for Advanced Medicine, the primary outpatient treatment center of UChicago Medicine.

microbiome bacteria

A donation of $100 million—the largest single gift to UChicago Medicine—establishes the Duchossois Family Institute: Harnessing the Microbiome and Immunity for Human Health.